Trimethyl phosphite → Dimethyl (2,5-dimethylbenzoyl)phosphonate

Reaction equation

[P:1]([O:6][CH3:7])([O:4][CH3:5])[O:2]C.[CH3:8][C:9]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:10]=1[C:11](Cl)=[O:12]>>[CH3:8][C:9]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:10]=1[C:11]([P:1](=[O:2])([O:6][CH3:7])[O:4][CH3:5])=[O:12]

Participants

Reactant 2

HCID 8472Trimethyl phosphite

HCID 123518852,5-Dimethylbenzoyl chloride

Product 1

HCID 13841501Dimethyl (2,5-dimethylbenzoyl)phosphonateYield 80%

Procedure

Dimethyl 2,5-dimethylbenzoylphosphonate was prepared in 80% yield by adding an equimolar amount of trimethyl phosphite to 2,5-dimethylbenzoyl chloride.

Sources & evidence

ORD record: ord-02a9843afde44163ad6a2062249227c4
Source dataset: uspto-grants-1983_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04416877

Reaction notes

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