HCID 15239992, compound → methyl 6-(N,N-dimethylamino)-3-hydroxypicolinate
Reaction equation
C([O:8][C:9]1[C:10]([C:18]([O:20][CH3:21])=[O:19])=[N:11][C:12]([N:15]([CH3:17])[CH3:16])=[CH:13][CH:14]=1)C1C=CC=CC=1>[C].[Pd].C(OCC)(=O)C>[CH3:17][N:15]([C:12]1[N:11]=[C:10]([C:18]([O:20][CH3:21])=[O:19])[C:9]([OH:8])=[CH:14][CH:13]=1)[CH3:16]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
2.3 g (8 mmol) of methyl 3-benzyloxy-6-(N,N-dimethylamino)picolinate and 0.3 g of 10% palladium carbon were added to 100 ml of ethyl acetate, and the mixture was hydrogenated under atmospheric pressure. After completion of the reaction, the product was filtered and concentrated to obtain crystals.
Workup
- customAfter completion of the reaction
- filtrationthe product was filtered
- concentrationconcentrated
- customto obtain crystals
Sources & evidence
- ORD record
- ord-119bbbed187147449d212ea1efbaeb9e
- Source dataset
- uspto-grants-1995_04
- Patent number
- US05403816
Reaction notes
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