Hydrazine hydrate (1:1) → 8-(3-Trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-(6H)-one

HRID 1653961

Reaction equation

HRID 1653961 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](O)=[O:11])=O.O.[NH2:23][NH2:24]>C(O)C>[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:6]2[C:8]3[N:16]=[CH:15][CH:14]=[CH:13][C:9]=3[C:10](=[O:11])[NH:24][N:23]=2)[CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 200788952-(3-Trifluoromethylbenzoyl)nicotinic acid

Product 1

HCID 200788638-(3-Trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-(6H)-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(3-trifluoromethylbenzoyl)nicotinic acid (1.5 g) and hydrazine hydrate (0.4 g) in ethanol was heated at the reflux temperature for 5 hours. On cooling and reduction of the volume of solvent by evaporation, a precipitate formed which was collected by filtration, to give the title compound as a white solid, 1.08 g, m.p. 210°-215° C.

Workup

  1. temperaturewas heated at the reflux temperature for 5 hours
  2. temperatureOn cooling
  3. customreduction of the volume of solvent by evaporation
  4. customa precipitate formed which
  5. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-9fe5b2bec79f4dce9192e2e36735ee5b
Source dataset
uspto-grants-1995_04
Patent number
US05405826

Linked notes

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