Piperidine → 2-Methyl-4-(piperidin-1-yl)pyridine
Reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH3:14])[CH:9]=1>O>[N:1]1([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([CH3:14])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Piperidine (31.7 ml) and 4 -chloro-2 -picoline (13.65 g) were heated together in a bomb at 170 ° for 4.5 hours. After cooling, the mixture was taken up in water and extracted with ether. After drying (K2CO3) and stripping, the residue was distilled to give 4 -piperidino-2 -picoline, 15.45 g, b.p. 105°-10 ° (0.1 mm).
Workup
- temperatureAfter cooling
- extractionextracted with ether
- dry with materialAfter drying (K2CO3)
- distillationthe residue was distilled
Sources & evidence
- ORD record
- ord-6f57cdeb9a6d4f848a172e397b916673
- Source dataset
- uspto-grants-1993_10
- Patent number
- US05250527
Reaction notes
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