2-Chlorobenzimidazole → Hydrochloric Acid

HRID 16556Notes

Reaction equation

HRID 16556 reaction equation
[Cl:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[C@H:11]1([NH2:21])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][CH2:12]1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:21][C@H:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][CH2:12]1.[ClH:1]

Participants

4

Reactant 2

HCID 785722-ChlorobenzimidazoleHCID 70580721-Aminotetralin, (R)-

Product 2

HCID 313Hydrochloric AcidHCID 11587013NS-8593

Procedure

The title compound was prepared from 2-chlorobenzimidazole and (R)-1,2,3,4-tetrahydro-l-naphthylamine by Procedure A (40 min at 170° C.). The product was filtered off and washed with acetonitrile to give the title compound as a HCl salt (white solid, mp 264-265° C.). MS(ES+) m/z 264 ([M+1]30, 100).

Workup

  1. filtrationThe product was filtered off
  2. washwashed with acetonitrile

Sources & evidence

ORD record
ord-20c8ebbf2dee4f958242e04dc6a1c9cc
Source dataset
uspto-grants-2010_06
Patent number
US07737167B2

Reaction notes

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