Hydrochloric Acid → 1,3-Dihydro-1',5-dimethylspiro[isobenzofuran-1,4'-piperidine]
Reaction equation
O[C:2]1([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=2[CH2:16][OH:17])[CH2:7][CH2:6][N:5]([CH3:8])[CH2:4][CH2:3]1.Cl>>[CH3:8][N:5]1[CH2:4][CH2:3][C:2]2([C:9]3[C:10](=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=3)[CH2:16][O:17]2)[CH2:7][CH2:6]1Participants
3
Procedure
Treatment of 4-hydroxy-4-(α-hydroxy-5-methyl-2-tolyl)-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 1,3-dihydro-1',5-dimethylspiro[isobenzofuran-1,4'-piperidine].
Sources & evidence
- ORD record
- ord-8befb265cc0c4632b1896c378e224bd6
- Source dataset
- uspto-grants-1976_06
- Patent number
- US03962259
Reaction notes
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