Methane → HCID 13310505, compound
Reaction equation
[ClH:1].C([NH:9][CH2:10][P:11](=[O:16])([O:14][CH3:15])[O:12][CH3:13])C1C=CC=CC=1.C>CO.C1C=CC=CC=1.[Pd]>[ClH:1].[NH2:9][CH2:10][P:11](=[O:16])([O:14][CH3:15])[O:12][CH3:13]Participants
6
Reactant 2
Product 1
Reagents, catalysts & solvents 3
Procedure
Dimethyl N-benzyl-aminomethylphosphonate hydrochloride (80.0 g) in methanol (800 ml) is hydrogenated at 40 psi with 10% palladium on powdered charcoal (4.0 g). The catalyst is removed by filtration through a pad of super cel. Evaporation of the methanolic filtrate gives a clear residue which is taken up in benzene. Removal of the benzene in vacuo affords crystalline dimethyl aminomethylphosphonate hydrochloride.
Workup
- customThe catalyst is removed by filtration through a pad of super cel
- customEvaporation of the methanolic filtrate
- customgives a clear residue which
- customRemoval of the benzene in vacuo
Sources & evidence
- ORD record
- ord-6718af19d98247e983271e20463a484f
- Source dataset
- uspto-grants-1976_06
- Patent number
- US03962224
Reaction notes
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