Oxygen → N-Ethylnicotinamide
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[O:8])[CH:2]=1.[CH2:9]([NH2:11])[CH3:10].O=O>[Pd]>[CH2:9]([NH:11][C:7](=[O:8])[C:3]1[CH:4]=[CH:5][CH:6]=[N:1][CH:2]=1)[CH3:10]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
In a 100 ml three-necked flask were charged 2 g of pyridine-3-aldehyde, 50 g of a 30 weight percent aqueous ethylamine solution and 3 g of the same commercially available palladium catalyst as in Example 1. The reaction was conducted at a reaction temperature of 30° C. for 2 hours by introducing oxygen at a rate of 10 l/hour into the flask from its gas inlet equipped with a filter to give nicotinic acid monoethylamide at a yield of 47%.
Workup
- customequipped with
- filtrationa filter
Sources & evidence
- ORD record
- ord-17723c827f74456db4a0cb4d50714e19
- Source dataset
- uspto-grants-1981_12
- Patent number
- US04304937
Reaction notes
Loading…