Heptane → CCR3 antagonist 1

4-Ethoxycarbonylmethyl-2-mercaptothiazole (70.14 g) was dissolved in a mixed solution of water (300 ml) and tert-butanol (250 ml), sodium hydroxide (29.46 g) was added on a water bath, and the mixture was stirred for 1.5 hr. To the reaction mixture was added a solution of (2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}chloroacetamide obtained in the above-mentioned 1-1 in tert-butyl methyl ether, and the mixture was stirred at 65° C. for 6 hr. n-Heptane (50 ml) and water (50 ml) were added to the reaction mixture, and the mixture was cooled to room temperature. The reaction mixture was stood still and partitioned, and the aqueous layer was further washed with a mixed solvent of tert-butyl methyl ether (200 ml)/n-heptane (20 ml). 6N Hydrochloric acid (60 ml) was added to the aqueous layer, and the mixture was extracted with ethyl acetate (750 ml) and further extracted twice with a mixed solvent of ethyl acetate (175 ml)/tert-butanol (20 ml). The obtained organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give a crude product (181 g) of compound 1-2.

1. additionwas added on a water bath
2. stirringthe mixture was stirred at 65° C. for 6 hr
3. custompartitioned
4. washthe aqueous layer was further washed with a mixed solvent of tert-butyl methyl ether (200 ml)/n-heptane (20 ml)
5. addition6N Hydrochloric acid (60 ml) was added to the aqueous layer
6. extractionthe mixture was extracted with ethyl acetate (750 ml)
7. extractionfurther extracted twice with a mixed solvent of ethyl acetate (175 ml)/tert-butanol (20 ml)
8. dry with materialThe obtained organic layer was dried over anhydrous sodium sulfate
9. customthe solvent was evaporated under reduced pressure

ORD record

ord-00e3972b69d449f6a3869f87fadf1892

Source dataset

uspto-grants-2011_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08030303B2