1-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-one → Methyl 2-ethyl-2-{[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}butanoate

HRID 16607

Reaction equation

HRID 16607 reaction equation
[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]1=[O:13])([CH3:3])[CH3:2].C([O:18][C:19]([NH:21][CH2:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:29][C:30]([CH2:37][CH3:38])([CH2:35][CH3:36])[C:31]([O:33][CH3:34])=[O:32])[CH2:25][CH2:24]1)=O)(C)(C)C>>[CH2:35]([C:30]([CH2:29][N:26]1[CH2:25][CH2:24][CH:23]([CH2:22][NH:21][C:19]([N:6]2[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:4]([CH:1]([CH3:3])[CH3:2])[C:5]2=[O:13])=[O:18])[CH2:28][CH2:27]1)([CH2:37][CH3:38])[C:31]([O:33][CH3:34])=[O:32])[CH3:36]

Participants

3

Reactant 2

HCID 16535801-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-oneHCID 67232103Methyl 2-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]-2-ethylbutanoate

Product 1

HCID 68585368Methyl 2-ethyl-2-{[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}butanoate

Procedure

The title compound was prepared according to the procedure described in Step 2 of Example 8 from 1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one and Methyl 2-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]-2-ethylbutanoate (step 1 of Example 13).

Sources & evidence

ORD record
ord-0fb8e1043ae94a52b72a56411923d592
Source dataset
uspto-grants-2010_06
Patent number
US07737163B2

Linked notes

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