Tetrahydrofuran → 3-(4-Methoxy-3-methyl-benzoyl)-1-(6-methyl-pyridin-2-ylmethyl)-1H-[1,5]naphthyridin-4-one

HRID 166124

Reaction equation

HRID 166124 reaction equation
[Br:23][CH2:24][c:25]1[n:26][c:27]([CH3:31])[cH:28][cH:29][cH:30]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:1][O:2][c:3]1[c:4]([CH3:22])[cH:5][c:6]([C:7](=[O:8])[c:9]2[cH:10][nH:11][c:12]3[cH:13][cH:14][cH:15][n:16][c:17]3[c:18]2=[O:19])[cH:20][cH:21]1.[CH3:32][SiH:33]([CH3:34])[N:35]([CH3:36])[Si:37]([CH3:38])([CH3:39])[CH3:40].[K:41]>>[CH3:1][O:2][c:3]1[c:4]([CH3:22])[cH:5][c:6]([C:7](=[O:8])[c:9]2[cH:10][n:11]([CH2:24][c:25]3[n:26][c:27]([CH3:31])[cH:28][cH:29][cH:30]3)[c:12]3[cH:13][cH:14][cH:15][n:16][c:17]3[c:18]2=[O:19])[cH:20][cH:21]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 589711N-dimethylsilyl-N-trimethylsilylmethanamineHCID 5462222PotassiumHCID 125437332-(Bromomethyl)-6-methylpyridineHCID 577546243-(4-Methoxy-3-methyl-benzoyl)-1H-[1,5]naphthyridin-4-one

Product 1

HCID 577547613-(4-Methoxy-3-methyl-benzoyl)-1-(6-methyl-pyridin-2-ylmethyl)-1H-[1,5]naphthyridin-4-one

Sources & evidence

ORD record
ord-079d676727d84b4b837119419f517fab
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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