Dimethylformamide → 1-(3-(7-Hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea

Reaction equation

[F:22][C:23]([C:24]([CH3:25])([CH3:26])[c:27]1[cH:28][c:29]([NH:32][C:33]([O:34][c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)=[O:35])[n:30][o:31]1)([F:42])[F:43].[NH2:1][c:2]1[cH:3][c:4]([O:5][c:6]2[n:7][cH:8][n:9][c:10]3[cH:11][c:12]([OH:18])[c:13]([O:16][CH3:17])[cH:14][c:15]23)[cH:19][cH:20][cH:21]1.[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[NH:1]([c:2]1[cH:3][c:4]([O:5][c:6]2[n:7][cH:8][n:9][c:10]3[cH:11][c:12]([OH:18])[c:13]([O:16][CH3:17])[cH:14][c:15]23)[cH:19][cH:20][cH:21]1)[C:33]([NH:32][c:29]1[cH:28][c:27]([C:24]([C:23]([F:22])([F:42])[F:43])([CH3:25])[CH3:26])[o:31][n:30]1)=[O:34]