Dichloromethane → tert-butyl N-[1-[3-[(2-bromo-1,3-thiazole-4-carbonyl)amino]-4-pyridinyl]piperidin-3-yl]carbamate

HRID 166234

Reaction equation

HRID 166234 reaction equation
[Br:22][c:23]1[s:24][cH:25][c:26]([C:28](=[O:29])[OH:30])[n:27]1.[CH2:31]([Cl:32])[Cl:33].[CH3:50][N+:51]([CH3:52])=[C:53]([N:54]([CH3:55])[CH3:56])[O:57][n:58]1[c:59]2[n:60][cH:61][cH:62][cH:63][c:64]2[n:65][n:66]1.[CH:34]([N:35]([CH2:36][CH3:37])[CH:38]([CH3:39])[CH3:40])([CH3:41])[CH3:42].[NH2:1][c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1[N:8]1[CH2:9][CH:10]([NH:14][C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:11][CH2:12][CH2:13]1.[P-:43]([F:44])([F:45])([F:46])([F:47])([F:48])[F:49]>>[NH:1]([c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1[N:8]1[CH2:9][CH:10]([NH:14][C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:11][CH2:12][CH2:13]1)[C:28]([c:26]1[cH:25][s:24][c:23]([Br:22])[n:27]1)=[O:29]

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 27632092-Bromo-1,3-thiazole-4-carboxylic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 67130164Tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate

Product 1

HCID 67501061tert-butyl N-[1-[3-[(2-bromo-1,3-thiazole-4-carbonyl)amino]-4-pyridinyl]piperidin-3-yl]carbamate

Sources & evidence

ORD record
ord-61a5f9a365af47bfabc897603f44af32
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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