C([Si]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=2[F:24])=[C:12]([C:25]2([O:30][CH3:31])[CH2:29][CH2:28][CH2:27][CH2:26]2)[CH:11]=1)(C)C)(C)(C)C.CC1C=CC(S([O-])(=O)=O)=CC=1.C1C=C[NH+]=CC=1>CO>[F:24][C:17]1[CH:18]=[CH:19][C:20]([O:22][CH3:23])=[CH:21][C:16]=1[C:13]1[CH:14]=[CH:15][C:10]([CH2:9][OH:8])=[CH:11][C:12]=1[C:25]1([O:30][CH3:31])[CH2:26][CH2:27][CH2:28][CH2:29]1To a solution of 66.68E (66 mg, 168 μmol) in MeOH, was added PPTS (11 mg, 45 μmol), and the mixture was stirred for 16 hours. Solvent was then removed in vacuo to give a residue which was purified by Combiflash chromatography to give the product as an oil (30 mg, 61%). MS ESI m/e: 331.2 (M+H)+.
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