Hydrazine hydrate (1:1) → 2-[4-(1-Naphthyl)-1-piperazinyl]ethanamine

HRID 1663023

Reaction equation

HRID 1663023 reaction equation
O.NN.[C:4]1([N:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][N:22]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:16][CH2:15]2)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][CH:5]=1>C(O)C>[C:4]1([N:14]2[CH2:15][CH2:16][N:17]([CH2:20][CH2:21][NH2:22])[CH2:18][CH2:19]2)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 210969322-{2-[4-(1-Naphthyl)-1-piperazinyl]ethyl}-1H-isoindole-1,3(2H)-dione

Product 1

HCID 47424972-[4-(1-Naphthyl)-1-piperazinyl]ethanamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.17 ml (3.55 mmol) of hydrazine monohydrate is added slowly at room temperature to a solution of 1.14 g (2.96 mmol) of 2-{2-[4-(1-naphthyl)-1-piperazinyl]ethyl}-1H-isoindole-1,3(2H)-dione, prepared in step 1.1, in 15 ml of ethanol. The reaction mixture is then refluxed for 1 hour.

Workup

  1. temperatureThe reaction mixture is then refluxed for 1 hour

Sources & evidence

ORD record
ord-208174d1adcc4ea1a55049b72803ef09
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Linked notes

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