Cl[CH2:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([O:14][C:15]3[CH:16]=[C:17]([NH:21][C:22](=[O:33])[C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=4)[CH:18]=[CH:19][CH:20]=3)=[N:10][N:9]2[CH:34]=1)=[O:4].[CH3:35][N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1>C(#N)C>[CH3:35][N:36]1[CH2:41][CH2:40][N:39]([CH2:2][C:3]([NH:5][C:6]2[N:7]=[C:8]3[CH:13]=[CH:12][C:11]([O:14][C:15]4[CH:16]=[C:17]([NH:21][C:22](=[O:33])[C:23]5[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=5)[CH:18]=[CH:19][CH:20]=4)=[N:10][N:9]3[CH:34]=2)=[O:4])[CH2:38][CH2:37]1Using N-[3-({2-[(chloroacetyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(trifluoromethyl)benzamide (120 mg, 0.244 mmol), 1-methylpiperazine (1 mL) and acetonitrile (2 mL) as starting materials and in the same manner as in Example 398, the title compound (67 mg, 50%) was obtained as a white powder.
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