Hydrochloric Acid → 2-Hydroxy-4-methoxy-4-oxobutan-1-aminium chloride

Reaction equation

[ClH:1].[NH2:2][CH2:3][CH:4]([OH:9])[CH2:5][C:6]([OH:8])=[O:7].[CH3:10]O>>[Cl-:1].[OH:9][CH:4]([CH2:5][C:6]([O:8][CH3:10])=[O:7])[CH2:3][NH3+:2]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 21494-Amino-3-hydroxybutanoic acid

Product 1

HCID 866201242-Hydroxy-4-methoxy-4-oxobutan-1-aminium chloride

Procedure

Anhydrous hydrochloric acid gas was bubbled into a suspension of 4-amino-3-hydroxybutanoic acid (0.91 g, 7.61 mmol) in methanol (150 mL) until the solution was saturated and stirred at ambient temperature. After 18 h, the solution was concentrated to give the title compound (1.32 g). MS 134 (M+1).