4-nitro-1-phenyl-1H-pyrazole → 1-Phenyl-1H-pyrazol-4-amine
Reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:8]=1)([O-])=O>CO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:8]=1Participants
5
Reactant 1
Product 1
Reagents, catalysts & solvents 3
Procedure
10% Pd/C (25 mg) was added to a stirred solution of 4-nitro-1-phenyl-1H-pyrazole (240 mg, 1.2 mmol) in a mixture of MeOH (2.5 mL) and EtOAc (2.5 mL) and stirred under H2 atmosphere overnight. The reaction mixture was filtered through celite and the filtrate so obtained was concentrated under reduced pressure to afford 140 mg (69365% Yield) of 4-amino-1-phenyl-1H-pyrazole.
Workup
- filtrationThe reaction mixture was filtered through celite
- customthe filtrate so obtained
- concentrationwas concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-345f202434ea4f7fbb743edc229a4c99
- Source dataset
- uspto-grants-2011_10
- Patent number
- US08039463B2
Reaction notes
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