Tetrahydrofuran → (+/-)-4-(5-(4-(2-Methylpropyl)phenyl)-1,2,4-oxadiazol-3-yl)-1-(1-hydroxyethyl)benzene

Reaction equation

[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:1][CH:2]([CH2:3][c:4]1[cH:5][cH:6][c:7](-[c:10]2[n:11][c:12](-[c:15]3[cH:16][cH:17][c:18]([CH2:21][OH:22])[cH:19][cH:20]3)[n:13][o:14]2)[cH:8][cH:9]1)[CH3:23].[CH3:25][Mg+:26].[I-:24]>>[CH3:1][CH:2]([CH2:3][c:4]1[cH:5][cH:6][c:7](-[c:10]2[n:11][c:12](-[c:15]3[cH:16][cH:17][c:18]([CH:21]([OH:22])[CH3:25])[cH:19][cH:20]3)[n:13][o:14]2)[cH:8][cH:9]1)[CH3:23]

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 30165Iodide Ion

HCID 11645224[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methanol

HCID 178477777HCID 178477777, compound

Product 1

HCID 18446989(+/-)-4-(5-(4-(2-Methylpropyl)phenyl)-1,2,4-oxadiazol-3-yl)-1-(1-hydroxyethyl)benzene

Sources & evidence

ORD record: ord-6fa85a48e3a74fe4b226abb6019c224c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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