Hydrochloric Acid → (R)-1-Morpholinopropan-2-amine hydrochloride
Reaction equation
[ClH:1].C(OC(=O)[NH:8][C@H:9]([CH3:17])[CH2:10][N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)(C)(C)C>O1CCOCC1.ClCCl>[ClH:1].[CH3:17][C@@H:9]([NH2:8])[CH2:10][N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Add 1.6 M hydrogen chloride in dioxane (120 mL) to a solution of (R)-(1-methyl-2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.05 mol, 12 g) in dry dichloromethane (75 mL) at 0° C. Warm the reaction mixture to room temperature and stir for 2 h. Filter the precipitate and dry under vacuum to obtain the title compound (9.2 g, 86%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 1.29 (d, 3H), 3.10 (br s, 2H), 3.38 (br s, 4H), 3.79 (br s, 5H).
Workup
- filtrationFilter the precipitate
- customdry under vacuum
Sources & evidence
- ORD record
- ord-a091f8028db64f6c9a5faa75143c990a
- Source dataset
- uspto-grants-2011_08
- Patent number
- US07994164B2
Reaction notes
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