Hydrogen chloride-ethyl acetate → 1-(Thiophen-2-YL)piperazine hydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:19].[S:15]1[CH:16]=[CH:17][CH:18]=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-(2-Thienyl)piperazine-1-carboxylic acid tert-butyl ester (700 mg) was dissolved in ethyl acetate (4 ml), a 4N hydrochloric acid-ethyl acetate solution (4 ml) was added, and the mixture was stirred at room temperature for 1.5 hr. The precipitated solid was collected by filtration, washed with ethyl acetate and dried to give 1-(2-thienyl)piperazine hydrochloride (532 mg, yield 98%).
Workup
- filtrationThe precipitated solid was collected by filtration
- washwashed with ethyl acetate
- customdried
Sources & evidence
- ORD record
- ord-277e2fd057094455b0f702445eeefb32
- Source dataset
- uspto-grants-2011_08
- Patent number
- US07994196B2
Reaction notes
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