Tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate → 4-(Benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid

HRID 1673444

Reaction equation

HRID 1673444 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:22]=[CH:21][C:13]([C:14]([O:16]C(C)(C)C)=[O:15])=[C:12]([NH:23][C:24](=[O:33])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=4[CH3:32])[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1>FC(F)(F)C(O)=O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:22]=[CH:21][C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:23][C:24](=[O:33])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=4[CH3:32])[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 1

HCID 67342913Tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate

Product 1

HCID 578794104-(Benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 31 mg of 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and methanol
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-9aa7eda3a966471e8efde12db1382b51
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Linked notes

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