Ethylamine → N-{[6-(Trifluoromethyl)pyridin-2-yl]methyl}ethanamine
Reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[N:8]=[C:7]([CH:9]=O)[CH:6]=[CH:5][CH:4]=1.[CH2:13]([NH2:15])[CH3:14]>C1COCC1>[CH2:13]([NH:15][CH2:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([C:2]([F:12])([F:11])[F:1])[N:8]=1)[CH3:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
prepared by reaction of 6-trifluoromethyl-pyridin-2-carbaldehyde (Ashimori A. Chem. Pharm. Bull. 1990, 38, 9, 2446-2458) with 2M ethylamine in THF.
Sources & evidence
- ORD record
- ord-be5038c4e0c94b9292b9653fbfdc4aee
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003654B2
Reaction notes
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