Ethylamine → Ethyl[(pyrimidin-5-yl)methyl]amine
Reaction equation
Cl[CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[N:7][CH:8]=1.[CH2:9]([NH2:11])[CH3:10]>C1COCC1>[CH2:9]([NH:11][CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[N:7][CH:8]=1)[CH3:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
prepared by reaction of the 5-chloromethyl-pyrimidine (Russell M. G. N et al J. Med. Chem. 2005, 48, 5, 1367-1383) with 2M ethylamine in THF.
Sources & evidence
- ORD record
- ord-eb39361f00d64d1b91b8dcb4ffd582e1
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003654B2
Reaction notes
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