Ethyl 2-(4-chloro-2-methoxyphenoxy)acetate → (4-Chloro-2-hydroxyphenoxy)acetic acid
Reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][C:8]([O:10]CC)=[O:9])=[C:4]([O:15]C)[CH:3]=1>Br>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([OH:15])[CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of the product from step (i) (2.7 g) in 48% aqueous hydrogen bromide (30 ml) was heated under reflux for 2 h. The solvent was evaporated, the residue washed with water and dried, yield 1.7 g.
Workup
- temperaturewas heated
- temperatureunder reflux for 2 h
- customThe solvent was evaporated
- washthe residue washed with water
- customdried
Sources & evidence
- ORD record
- ord-542d1ec0fffa4e2da579595d4a701482
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003703B2
Reaction notes
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