Toluene → Ethyl 2-(4-(2-(1-(tert-butoxycarbonyl)piperidin-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)nicotinate

Reaction equation

Cl[C:2]1[N:12]=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].C([O-])([O-])=O.[Cs+].[Cs+].[NH2:19][C:20]1[CH:48]=[CH:47][C:23]([O:24][C:25]2[CH:30]=[CH:29][N:28]=[C:27]3[CH:31]=[C:32]([CH:34]4[CH2:39][CH2:38][N:37]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:36][CH2:35]4)[S:33][C:26]=23)=[C:22]([F:49])[CH:21]=1.C1(C)C=CC=CC=1>O.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.CCO>[C:43]([O:42][C:40]([N:37]1[CH2:38][CH2:39][CH:34]([C:32]2[S:33][C:26]3[C:27](=[N:28][CH:29]=[CH:30][C:25]=3[O:24][C:23]3[CH:47]=[CH:48][C:20]([NH:19][C:2]4[N:12]=[CH:11][CH:10]=[CH:9][C:3]=4[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:21][C:22]=3[F:49])[CH:31]=2)[CH2:35][CH2:36]1)=[O:41])([CH3:46])([CH3:44])[CH3:45]