Hydrochloric Acid → 1-(2,2-Difluoroethyl)piperidin-4-amine Dihydrochloride
Reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([F:17])[F:16])[CH2:10][CH2:9]1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[ClH:19].[F:17][CH:15]([F:16])[CH2:14][N:11]1[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1Participants
4
Procedure
To a cooled (0 degrees) mixture of 1.21 g (4.58 mmole) of [1-(2,2-difluoro-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 20 mL of dioxane, was added 5.7 mL of 4M HCl in dioxane. The mixture was stirred at room temperature overnight, and the solid collected by filtration to give 0.90 g of 1-(2,2-difluoro-ethyl)-piperidin-4-ylamine dihydrochloride.
Workup
- temperatureTo a cooled
- filtrationthe solid collected by filtration
Sources & evidence
- ORD record
- ord-e09a25ffa64343cc9ed69e9edec03e59
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003785B2
Reaction notes
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