2'-Methyl-5'-(4-morpholin-4-yl-benzoylamino)-biphenyl-4-carboxylic acid ethyl ester → 2'-Methyl-5'-(4-morpholin-4-yl-benzoylamino)-biphenyl-4-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19](=[O:32])[C:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[CH:22][CH:21]=3)[CH:15]=[CH:14][C:13]=2[CH3:33])=[CH:8][CH:7]=1)=[O:5])C>C1COCC1.[OH-].[Na+]>[CH3:33][C:13]1[CH:14]=[CH:15][C:16]([NH:18][C:19](=[O:32])[C:20]2[CH:21]=[CH:22][C:23]([N:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)=[CH:24][CH:25]=2)=[CH:17][C:12]=1[C:9]1[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=1Participants
4
Procedure
2′-Methyl-5′-(4-morpholin-4-yl-benzoylamino)-biphenyl-4-carboxylic acid ethyl ester (2.4 g) was stirred in a mixture of THF (25 ml) and 1M sodium hydroxide (50 ml) at 10° C. for 4 h. The mixture was allowed to cool and the THF was evaporated. The residue was acidified and the resultant colourless precipitate collected by filtration and dried (1.98 g).