Hydrochloric Acid → 5-Bromo-3-phenylbenzo[b]thiophene-2-carboxylic acid
Reaction equation
[Br:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][C:7]([C:15]([O:17]C)=[O:16])=[C:8]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:4]=2[CH:3]=1.[OH-].[Na+].Cl>CO>[Br:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][C:7]([C:15]([OH:17])=[O:16])=[C:8]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:4]=2[CH:3]=1Participants
5
Procedure
Heat 3 g. of methyl 5-bromo-3-phenyl-benzo[b]-thiophene-2-carboxylate in a mixture of 50 ml. of methanol and 30 ml. of 10% sodium hydroxide under reflux for one hour. Add concentrated hydrochloric acid to yield the title compound as a precipitate. Recrystallize it from benzene; m.p. 265°-266°.
Workup
- temperatureHeat 3 g
Sources & evidence
- ORD record
- ord-1165f39fe2bd424e87269c221f2f7568
- Source dataset
- uspto-grants-1978_03
- Patent number
- US04081549
Reaction notes
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