Trifluoroacetic acid → HCID 86735587, compound
Reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH2:4][NH:5][C:6](=[O:21])[C@H:7]([CH3:20])[NH:8][C:9](=[O:19])[CH2:10][NH:11]C(OC(C)(C)C)=O.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[CH3:1][O:2][C:3](=[O:22])[CH2:4][NH:5][C:6](=[O:21])[C@H:7]([CH3:20])[NH:8][C:9](=[O:19])[CH2:10][NH2:11]Participants
3
Conditions
- Temperature
- 0 °C
Procedure
Boc-Gly-Ala-Gly-OMe (6.4 g, 20.1 mmoles, described in Example 2) is dissolved in cold (ice bath) trifluoroacetic acid (120 ml) and the solution stirred at 0° C for 1 hr. The solvent is evaporated, the residue dissolved in methanol and the product precipitated with the addition of diethyl ether. The precipitiate is collected to give the title compound.
Workup
- customThe solvent is evaporated
- dissolutionthe residue dissolved in methanol