Triethylamine → 3-Methyl-carbamoylmercapto-4-n-butyl-1,2,4-triazole
Reaction equation
[SH:1][C:2]1[N:6]([CH2:7][CH2:8][CH2:9][CH3:10])[CH:5]=[N:4][N:3]=1.[CH2:11](N(CC)CC)C.C[N:19]=[C:20]=[O:21]>CCOCC>[CH3:11][C:5]1[N:6]([CH2:7][CH2:8][CH2:9][CH3:10])[C:2]([S:1][C:20](=[O:21])[NH2:19])=[N:3][N:4]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To 6.0 g. (0.0382 mole) of 3-mercapto-4-n-butyl-1,2,4-triazole dissolved in 50 ml. of ether was added 2.5 g. (0.248 mole) of triethylamine and then 2.5 g. (0.0438 mole) of methyl isocyanate. The resulting orange-brown solution was allowed to stand overnight. The solid which formed was filtered and washed twice with 50 ml. of ether to give 4.7 g. (57% yield) of 3-methyl-carbamoylmercapto-4-n-butyl-1,2,4-triazole melting at 112°-114° C.
Workup
- customThe solid which formed
- filtrationwas filtered
- washwashed twice with 50 ml
- customof ether to give 4.7 g
Sources & evidence
- ORD record
- ord-e37b7f61273247a1976cbc006efbe8f9
- Source dataset
- uspto-grants-1981_06
- Patent number
- US04271308
Reaction notes
Loading…