Hydrazine hydrate (1:1) → 6-Hydrazinyl-5-methoxy-3-pyridinesulfonamide
Reaction equation
Cl[C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([S:10](=[O:13])(=[O:12])[NH2:11])=[CH:4][N:3]=1.O.[NH2:15][NH2:16]>CO>[NH:15]([C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([S:10](=[O:13])(=[O:12])[NH2:11])=[CH:4][N:3]=1)[NH2:16]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Chloro-3-methoxy-5-sulfamoylpyridine (0.3 g, 1.35×10-3 mole) and hydrazine hydrate (0.53 g, approximately 0.01 mole) were added to methanol (20 ml). After refluxing overnight, the reaction mixture was stripped of methanol in vacuo to yield an oil which was cooled in an ice bath and triturated with water (5 ml). The precipitate was collected by filtration and air dried; yield, 0.22 g (75 percent).
Workup
- temperatureAfter refluxing overnight
- customto yield an oil which
- temperaturewas cooled in an ice bath
- customtriturated with water (5 ml)
- filtrationThe precipitate was collected by filtration and air
- customdried
- customyield
Sources & evidence
- ORD record
- ord-608a8918b7ad4a2e8c10452b88540f13
- Source dataset
- uspto-grants-1981_06
- Patent number
- US04273706
Reaction notes
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