Methanol → 1-Cyclopropylpiperazine

HRID 16819

Reaction equation

HRID 16819 reaction equation
Cl.Cl.[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1.CO>O>[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 887MethanolHCID 212208121-Cyclopropylpiperazine dihydrochloride

Product 1

HCID 47420041-CyclopropylpiperazineYield 84.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Cyclopropylpiperazine dihydrochloride (1.493 g, 7.5 mmol) was dissolved in water (5.00 mL) and methanol (5.00 mL) and converted to its freebase by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 3.5M ammonia in methanol and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.796 g, 84%) as an oil.

Workup

  1. washThe desired product was eluted from the column
  2. customwere evaporated to dryness

Sources & evidence

ORD record
ord-52133c47f1534988bfc9e04dd961a467
Source dataset
uspto-grants-2010_06
Patent number
US07737149B2

Linked notes

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