1-Cyclopropylpiperazine
Basic information
- CAS
20327-23-5- Standard SMILES
C1CN(C2CC2)CCN1- InChIKey
HNZJIWIXRPBFAN-UHFFFAOYSA-N- Molecular formula
- C7H14N2
- Average molar mass
- 126.2 g/mol
- Monoisotopic mass
- 126.11569845
Names & identifiers
- Preferred name
- 1-Cyclopropylpiperazine
- IUPAC
- 1-cyclopropylpiperazine
- English name
- 1-Cyclopropylpiperazine
- Molecular formula
- C7H14N2
- Molecular weight
- 126.2
Names & synonyms
1-Cyclopropylpiperazine20327-23-5DTXSID20406303RefChem:229876DTXCID30357155807-993-7Piperazine, 1-cyclopropyl-MFCD062548051-CYCLOPROPYL-PIPERAZINEcyclopropyl piperazineN-CYCLOPROPYLPIPERAZINE(Piperazin-1-yl)cyclopropane
Show more names
1-Cyclopropylpiperazine >(Piperazin-1-yl)cyclopropane1-(Cyclopropyl Phenyl)Piperazine1-Cyclopropylpiperazine - [C14363]1-Cyclopropylpiperazine ISO 9001：2015 REACH
cyclopropylpiperazinecyclopropylpiper-azinen-cyclopropyl-piperazineN-cyclopropyl piperazinePiperazine,1-cyclopropyl-SCHEMBL63548SCHEMBL188355SCHEMBL894571
Database identifiers
- CAS
20327-23-5- PubChem CID
- 4742004
- DTXSID
DTXSID20406303- EC Number
- 807-993-7
Properties
Computed structural properties
- XLogP
- 0.2
- Topological polar surface area
- 15.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 93.1
Physicochemical properties
- Boiling point
- 43 °C/7mm · 43°C/7mm
- Density
- 0.94 · 0.94
- refractive index
- 1.4804 · 1.4804
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 9.23 · 9.23±0.10(Predicted)
- color
- Colorless to Light yellow
- InChI
- InChI=1S/C7H14N2/c1-2-7(1)9-5-3-8-4-6-9/h7-8H,1-6H2
- InChIKey
- HNZJIWIXRPBFAN-UHFFFAOYSA-N
- SMILES
- N1(C2CC2)CCNCC1
- Symbol(GHS)
- 5 · GHS05
- Signal word
- Danger
- Hazard statements
- 314 · H314-H227
- Precautionary statements
- 501 · P501-P210-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405
- Hazard Codes
- Xi
- RIDADR
- 3267 · 3267
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 5 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (60%)
Safety data
- ridadr
- 3267
- hs_code
- 2933599590
- Signal word
- Danger
- Symbol(GHS)
- GHS05
- hazard_code
- Xi
- hazard_class
- 8
- packing_group
- Ⅲ
- Hazard statements
- H314-H227
- Precautionary statements
- P501-P210-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405
Chemistry & industry
Applications
Uses1-cyclopropylpiperazine is a piperazine derivative known in the literature by synonyms such as N-cyclopropylpiperazine and 4-cyclopropylpiperazine. It has been used in the preparation of some tri- and tetrasubstituted ureas with histamine H3 antagonist receptor activity, 3-amido-4- anilinoquinolines series as CSF-1R kinase inhibitors, for the synthesis of cyclopropyl amines as modulators of the histamine H3 receptor, sulfonamide compounds as cysteine protease inhibitors, N-oxides as antibacterial agents and in the treatment of the disease caused by helicobacter infection[1].
Upstream & downstream products
Upstream raw materials
Related reactions
71 records
Compound notes
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