Hydrochloric Acid → HCID 54534355, compound
Reaction equation
[NH2:1][CH:2](/[CH:6]=[CH:7]/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])[C:3]([OH:5])=[O:4].Cl.[CH2:14](O)[CH3:15]>>[CH2:14]([O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH:6]=[CH:7][CH2:8][P:9]([OH:12])([OH:11])=[O:10])[CH3:15]Participants
4
Procedure
2.0 g of E-2-amino-5-phosphono-3-pentenoic acid are placed in 50 ml of ethanol and the whole is saturated with hydrogen chloride gas for 21/2 hours at 50°. After concentration, the residue is dissolved in 18 ml of ethanol, 18 ml of propylene oxide are added and the precipitate is filtered off. Recrystallisation from water/ethanol 1:3 yields 2-amino-5-phosphono-3-pentenoic acid ethyl ester, m.p. 167°-168°.
Workup
- custom2 hours
- customat 50°
- concentrationAfter concentration
- dissolutionthe residue is dissolved in 18 ml of ethanol
- addition18 ml of propylene oxide are added
- filtrationthe precipitate is filtered off
- customRecrystallisation from water/ethanol 1:3
Sources & evidence
- ORD record
- ord-74fd015913e14ff1a7ad333c6ea33371
- Source dataset
- uspto-grants-1992_12
- Patent number
- US05175344
Reaction notes
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