[1-(3-Oxobut-1-en-1-yl)cyclopropyl]acetonitrile → [1-(3-Oxobutan-1-yl)cyclopropyl]acetonitrile
Reaction equation
[O:1]=[C:2]([CH3:11])[CH:3]=[CH:4][C:5]1([CH2:8][C:9]#[N:10])[CH2:7][CH2:6]1.[H][H]>C(OCC)(=O)C.[Pd]>[O:1]=[C:2]([CH3:11])[CH2:3][CH2:4][C:5]1([CH2:8][C:9]#[N:10])[CH2:7][CH2:6]1Participants
5
Procedure
A solution of the olefin from Step 1 (4.08 g, 26.8 mmol) in 85 mL ethyl acetate was treated with 30 psi hydrogen over 5% palladium on carbon (300 rag) in a Parr shaker for 1.5 h. The mixture was filtered through celite and evaporated to give 4.1 g of the title compound.
Workup
- filtrationThe mixture was filtered through celite
- customevaporated
Sources & evidence
- ORD record
- ord-2694639149ec464c8d04aacd39c273a7
- Source dataset
- uspto-grants-1997_06
- Patent number
- US05639780
Reaction notes
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