Hydrochloric Acid → 2-Amino-5-fluorothiazole dihydrochloride salt
Reaction equation
C(OC([NH:8][C:9]1[S:10][C:11]([F:19])=[C:12](CN(OC)C)[N:13]=1)=O)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[NH2:8][C:9]1[S:10][C:11]([F:19])=[CH:12][N:13]=1Participants
4
Procedure
A solution of 2-(tert-butoxycarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)-5-fluorothiazole (3.6 g, 12.4 mmol) in 1,4-dioxane (60 mL) was saturated with dry HCl gas and held overnight. The mixture was evaporated to dryness to leave the 2-amino-5-fluorothiazole dihydrochloride salt (3.3 g, 100% yield).
Workup
- customThe mixture was evaporated to dryness
Sources & evidence
- ORD record
- ord-be1fefd668674bd1b939952a68b83d98
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08148380B2
Reaction notes
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