Acetone → Methyl(4-chloro-3-methoxyphenyl)acetate
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]C(O)=O)=[CH:4][C:3]=1[OH:12].S([O:18][CH3:19])(OC)(=O)=O.[C:20](=[O:23])([O-])[O-].[K+].[K+].[CH3:26]C(C)=O>O>[CH3:20][O:23][C:19](=[O:18])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([O:12][CH3:26])[CH:4]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
The product of example 1 step (iii) (1 g), dimethyl sulfate (1 ml), potassium carbonate (1.48 g) and acetone (20 ml) were charged to a flask and heated at reflux for 16 h. The reaction was diluted with water, extracted with EtOAc, dried (MgSO4) and evaporated under reduced pressure to give the subtitle compound (1.5 g).
Workup
- temperatureheated
- temperatureat reflux for 16 h
- extractionextracted with EtOAc
- dry with materialdried (MgSO4)
- customevaporated under reduced pressure
Sources & evidence
- ORD record
- ord-79a0e8db07cf4083a40355f7741959dd
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08148572B2
Reaction notes
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