Acetic Acid → HCID 86633984, compound
Reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]2[C:18]([Cl:19])=[CH:17][N:16]=[C:15]([Cl:20])[N:14]=2)[CH:3]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22].C1COCC1.C(O)(=O)C>>[C:21]([NH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([NH:12][C:13]2[C:18]([Cl:19])=[CH:17][N:16]=[C:15]([Cl:20])[N:14]=2)[CH:3]=1)(=[O:23])[CH3:22]Participants
5
Procedure
4-Amino-2-(2,5-dichloro-pyrimidin-4-ylamino)-N-methyl-benzamide (0.135 g, 0.000432 mol), Acetic anhydride (0.0428 mL, 0.000454 mol), THF (5 mL, 0.06 mol) and Acetic acid (0.024 mL, 0.43 mol) were stirred at rt for 16 h. Product isolated as white ppt (80 mg, 52%).