Hydrochloric Acid → 1-(Pyrimidin-4-yl)cyclopropan-1-amine hydrochloride
Reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([NH:10]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)=[N:3][CH:2]=1.[ClH:18]>O1CCOCC1>[ClH:18].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([NH2:10])[CH2:9][CH2:8]2)=[N:3][CH:2]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of tert-butyl 1-(pyrimidin-4-yl)cyclopropylcarbamate (0.100 g, 0.425 mmol, 1.0 eq), in 4.0 M HCl in 1,4-dioxane (4.0 ml) was stirred at r.t. for 5 hr. The reaction mixture was concentrated completely and the HCl salt was taken to next step.
Workup
- concentrationThe reaction mixture was concentrated completely
Sources & evidence
- ORD record
- ord-60c2ef00b38140d282407e8cf8958170
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08148382B2
Reaction notes
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