Hydrochloric Acid → HCID 59753698, compound
Reaction equation
[F:1][C:2]1[CH:45]=[CH:44][C:5]([CH2:6][C@H:7]([NH:31][C:32]([C:34]2[NH:43][C:37]3=[CH:38][N:39]=[C:40]([Cl:42])[CH:41]=[C:36]3[CH:35]=2)=[O:33])[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][N:17]([CH3:30])S(C3C=CC=CC=3[N+]([O-])=O)(=O)=O)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.C(OC(N1CCC(CN)CC1)=O)(C)(C)C.Cl>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C@H:7]([NH:31][C:32]([C:34]2[NH:43][C:37]3=[CH:38][N:39]=[C:40]([Cl:42])[CH:41]=[C:36]3[CH:35]=2)=[O:33])[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][NH:17][CH3:30])[CH2:12][CH2:11]2)=[O:9])=[CH:44][CH:45]=1Participants
4
Procedure
Prepared according to EXAMPLE 191 from 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(4-fluorobenzyl)-2-(4-{[methyl-(2-nitrobenzenesulfonyl)amino]methyl}piperidin-1-yl)-2-oxoethyl]amide (synthesised according to Preparations 73-76 from the 4-aminomethylpiperidine-1-carboxylic acid tert-butyl ester starting material). m/z (ES+) free base=472.33 [M+H]+; RT=2.80 min. m/z (ES+) HCl salt=430.43 [M+H]+; RT=2.72 min.