4-Bromo-N,N-dimethylbenzenesulphonamide → [[5-Chloro-4'-[(dimethylamino)sulfonyl][1,1'-biphenyl]-2-yl]oxy]-(2s)-propanoic acid

HRID 1694747

Reaction equation

HRID 1694747 reaction equation
B([C:4]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:5]=1[O:6][C@@H:7]([CH3:11])[C:8]([OH:10])=[O:9])(O)O.Br[C:18]1[CH:23]=[CH:22][C:21]([S:24]([N:27]([CH3:29])[CH3:28])(=[O:26])=[O:25])=[CH:20][CH:19]=1>C1COCC1>[Cl:16][C:14]1[CH:13]=[CH:12][C:5]([O:6][C@@H:7]([CH3:11])[C:8]([OH:10])=[O:9])=[C:4]([C:18]2[CH:19]=[CH:20][C:21]([S:24]([N:27]([CH3:29])[CH3:28])(=[O:25])=[O:26])=[CH:22][CH:23]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 128184-Bromo-N,N-dimethylbenzenesulphonamideHCID 67277298(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

Product 1

HCID 11429045[[5-Chloro-4'-[(dimethylamino)sulfonyl][1,1'-biphenyl]-2-yl]oxy]-(2s)-propanoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by the method of example 144 step (i) using the product from step (iv) and 4-bromo-N,N-dimethylbenzenesulfonamide and THF as solvent. Yield (0.068 g).

Workup

  1. customYield (0.068 g)

Sources & evidence

ORD record
ord-9b4d93441cba419b8d4b27d060596aed
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Linked notes

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