Pyrrolidine → 1-[(4-Bromo-2-fluorophenyl)carbonyl]pyrrolidine
Reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:8])=[C:4]([F:11])[CH:3]=1Participants
3
Procedure
The sub-title compound was prepared by the method of example 18 step a) using 4-bromo-2-fluoro-benzoic acid and pyrrolidine.
Sources & evidence
- ORD record
- ord-1cccd8b79790426d8ee474b27887f344
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08163727B2
Reaction notes
Loading…