Hydrochloric Acid → (3S)-1-(pyridin-2-yl)pyrrolidin-3-amine dihydrochloride
Reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH2:9]1)(C)(C)C.[ClH:20]>O1CCOCC1.CO>[ClH:20].[ClH:20].[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[N:10]1[CH2:11][CH2:12][C@H:8]([NH2:7])[CH2:9]1Participants
5
Procedure
To a solution of ((S)-1-pyridin-2-yl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester (0.221 g, 0.84 mmol) in dioxane (4 ml) and methanol (1 ml) is added 4M HCl (in dioxane) (0.525 ml, 2.1 mmol) and the reaction mixture is stirred at room temperature overnight. The resulting suspension is filtered and washed with dioxane (3×1 ml) to yield the titled compound.
Workup
- filtrationThe resulting suspension is filtered
- washwashed with dioxane (3×1 ml)
Sources & evidence
- ORD record
- ord-d91c1a81bd5342dfb12cfb43bee656b5
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08163754B2
Reaction notes
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