Methanol → 4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

HRID 169816

Reaction equation

HRID 169816 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][cH:16][c:17]([C:20](=[O:21])[O:22][CH3:23])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[CH3:31][OH:32].[Na+:30].[OH-:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][cH:16][c:17]([C:20](=[O:21])[OH:22])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 8028TetrahydrofuranHCID 22492933Tert-butyl 4-[4-(methoxycarbonyl)phenyl]-1-piperidinecarboxylate

Product 1

HCID 224928594-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-8259ceb4f61649469588327e916a1c62
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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