Ammonium Acetate → HCID 18317628, compound
Reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[CH2:12][C:11](=O)[CH2:10][C:9](=[O:14])[CH2:8]1.C([O-])(=O)C.[NH4+:19]>C(O)C>[NH2:19][C:11]1[CH2:12][CH:7]([C:3]2[S:4][CH:5]=[CH:6][C:2]=2[CH3:1])[CH2:8][C:9](=[O:14])[CH:10]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 5-(3-methyl-2-thienyl)-1,3-cyclohexanedione (3.0 g) and ammonium acetate (3.3 g) in ethanol (60 ml) was refluxed for 13 hours. Under reduced pressure, the solvent was evaporated, and to the residue were added ethyl acetate and water to precipitate crystals, which were filtered, washed with water and dried to give pale yellow crystals of 1-amino-5-(3-methyl-2-thienyl)cyclohexen-3-one (2.7 g).
Workup
- customUnder reduced pressure, the solvent was evaporated
- additionto the residue were added ethyl acetate and water
- customto precipitate crystals, which
- filtrationwere filtered
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-0fc25c4ade1f4ffe8201f981d3b736d6
- Source dataset
- uspto-grants-2002_02
- Patent number
- US06350749B1
Reaction notes
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