4,5-Dichloro-2-methylaniline → 5-Chloro-2-methylaniline

HRID 1701494

Reaction equation

HRID 1701494 reaction equation
Cl[C:2]1[C:8]([Cl:9])=[CH:7][C:5]([NH2:6])=[C:4]([CH3:10])[CH:3]=1>O.Cl>[Cl:9][C:8]1[CH:2]=[CH:3][C:4]([CH3:10])=[C:5]([CH:7]=1)[NH2:6]

Participants

4

Reactant 1

HCID 3437964,5-Dichloro-2-methylaniline

Product 1

HCID 72605-Chloro-2-methylanilineYield 82%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

Following the general procedure I, 0.25 mol of 4,5-dichloro-2-methylaniline in 200 ml of water and 60 ml of concentrated hydrochloric acid are hydrogenated in the presence of the catalyst from Example 1 at 220° C. over the course of 30 minutes under a hydrogen pressure of 100 atmospheres gauge. 5-Chloro-2-methylaniline is obtained in a yield of 82% and a purity of 99%.

Sources & evidence

ORD record
ord-8037112fe81848e297759b0be669a25f
Source dataset
uspto-grants-1980_03
Patent number
US04193937

Linked notes

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