Benzyl Chloride → 4'-Benzyloxy-2'-hydroxyacetophenone

HRID 1702580Notes

Reaction equation

[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].C(C1C=CC=CC=1)(=O)C.[CH3:24][C:25]([C:27]1[CH:28]=[CH:29][C:30]([OH:34])=[CH:31][C:32]=1[OH:33])=[O:26]>>[CH3:24][C:25]([C:27]1[CH:28]=[CH:29][C:30]([O:34][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:31][C:32]=1[OH:33])=[O:26]

Participants

Reactant 3

HCID 7503Benzyl Chloride

HCID 11430Potassium Carbonate

HCID 20525554Acetophenone 2,4-dihydroxyacetophenone

Product 1

HCID 3092574'-Benzyloxy-2'-hydroxyacetophenone

Procedure

The reaction of (1) above is repeated using 1.1 molar equivalents of benzyl chloride, 1.0 molar equivalent of K2CO3, and substituting for the above acetophenone 2,4-dihydroxyacetophenone ##STR17##

Sources & evidence

ORD record: ord-101bb68d5317448bae34392cba41218f
Source dataset: uspto-grants-1982_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04348333

Reaction notes

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