Triethylamine → 2-(Isocyanatomethyl)bicyclo[2.2.1]heptane
Reaction equation
[C:1]12(CC(O)=O)[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:19])C=CC=CC=1.[CH2:29]([N:31]([CH2:34]C)CC)C>C1C=CC=CC=1>[CH:1]12[CH2:7][CH:4]([CH2:3][CH2:2]1)[CH2:5][CH:6]2[CH2:29][N:31]=[C:34]=[O:19]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The reaction of 2-norbornylacetic acid and diphenylphosphoryl azide in a solution of triethylamine and benzene provided a solution comprising 2-norbornylmethyl isocyanate (I.R.: 2270 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-(2-norbornylmethyl)carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 1.
Sources & evidence
- ORD record
- ord-8143a1ff7c25439ba16ed12c08638b81
- Source dataset
- uspto-grants-1982_09
- Patent number
- US04349552
Reaction notes
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