Hydrochloric Acid → 5-(Chloromethyl)uracil

HRID 1703050

Reaction equation

HRID 1703050 reaction equation
O[CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.[ClH:11]>>[Cl:11][CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 781685-(Hydroxymethyl)uracil

Product 1

HCID 2361255-(Chloromethyl)uracil

Procedure

A solution of 1.4 g. (0.010 mole) of 5-hydroxymethyl uracil in 12.5 ml. of concentrated hydrochloric acid was prepared. A colorless precipitate (5-chloromethyl uracil) formed within two minutes and after about ten minutes the precipitate was collected by filtration, washed rapidly with ice cold water, dried and then suspended in 10 ml. of dimethylformamide.

Sources & evidence

ORD record
ord-4dcebf16c68b4e21871e38c7da8478f6
Source dataset
uspto-grants-1982_09
Patent number
US04350754

Linked notes

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